Abstract
An upper airway allergy to inhaled or ingested allergens may induce an abnormal sensation in the throat (AST). However, little has been investigated about the incidence of allergic patients among patients with AST.Using the AlaSTAT system, we measured total IgE levels and antigen-specific IgE antibodies to pollen (cedar, cypress, birch), house dust, apple and two broad screening panels of food in 182 patients (75 males and 107 females; mean age was 57.7 years) with AST.Eighty-eight (48.4%) of 182 patients showed abnormally high (250<U/ml) total IgE levels and/or a positive (AlaSTAT class 1≤) IgE antibody to one or more allergens. These patients were classified into group A and compared with the other patients (group Non-A).A statistically significant difference (p<0.05 by Mann-Whitney U test) between groups A and Non-A was shown for the total IgE value (A>Non-A), average age (A<Non-A), average month after the onset of AST (A<Non-A), location of AST and average CIJ score by the Cornell Medical Index-Health Questionnaire. These findings indicate that upper airway allergies should be taken into consideration as a cause of AST.
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