Abstract
Pemphigus is an antibody-mediated autoimmune skin disease that causes blistering of oral mucous membranes as well as skin, and it is generally considered that the blisters are induced by loss of cell to cell contact in the keratinocytes. However, the details are still unclear. In order to investigate the molecular mechanism of blister formation in oral mucous membranes, we observed the effects of pemphigus antibody on the organization of keratin intermediate filaments (KIFs) in cultured oral keratinocytes. After incubation with serum obtained from a patient with pemphigus vulgaris for 96 hrs at 37°C, the distribution of KIFs was changed from a fibrous structure to a dotted structure around the nucleus in some of the cells from normal gingiva and soft palate, but such changes were not observed in cells from normal tongue. These results suggest that the keratinocytes from the gingiva and soft palate may be more sensitive to the pemphigus antibody than cells from the tongue.
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