Abstract
Reconstructive musculoskeletal surgery is important for preventing infections. Usually, antibiotics are used for this aim. The concentration of antibiotics must exceed MIC in the venous blood and bone marrow. In this study, we measured the concentration of Isepamicin of venous blood and bone marrow.The subjects consisted of 8 males and 1 female who underwent reconstruction of the rotator cuff. Their ages ranged from 36 to 66 years (average 54.6). Four hundred mg of Isepamicin was administered intravenously during 60 minutes. Their venous blood and bone marrow were taken immediately after the admistration, 30 minutes later, and 60 minutes later. The blood of the bone marrow was extracted from the bony sulcus made on the humeral head during the operation. The serum of the venous blood and bone marrow was measured to determine the concentration of the Isepamicin.There were no statistical significance between the Isepamicin concentrations of venous blood and bone marrow. They were higher than MIC to prevent infections in both venous blood and bone marrow. No side effects of Isepamicin were found in all cases. The shift to the bone marrow of Isepamicin administered intravenously was excellent.
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