铜钴锡硫纳米晶的制备及核磁共振成像应用

Abstract

采用溶剂热法制备了小尺寸铜钴锡硫(CCTS)纳米晶，通过X射线粉末衍射(XRD)、透射电子显微镜(TEM)、紫外可见光吸收光谱(UV-Vis)等多种手段对CCTS的尺寸、形貌，结构和组成进行表征。结果表明，产物为尺寸均一、分散性良好的纳米晶，平均粒径为13.2 nm。利用临床用3.0T核磁共振成像仪表征CCTS的T1成像效果，发现不同浓度CCTS溶液在MRI成像时具有显著的增强效果，重要的是其r1值为7.64 mM−1S−1，而且荷瘤小鼠尾静脉注射时可以显著增强肿瘤的成像效果。CCTS纳米晶具有优越的核磁共振成像增强作用，在MRI成像应用领域具有广阔的前景。 Small Cu2CoSnS4(CCTS) nanocrystals were synthesized via a facile solvothermal method in large quantity. The morphology, size, structure and composition of the as-synthesized CCTS were char-acterized by XRD, TEM, and UV-Visible absorption spectra. The results showed that the products were nanocrystals with average particle size of 13.2 nm, uniform size and good dispersibility. T1weighted MR images of CCTS solutions were acquired on a 3.0-T clinical MR scanner, revealing the obvious concentration-dependent brightening effect. Importantly, the r1 value increased dramatically from the initial value to 7.64 mM−1S−1. Remarkable brightening effect in the tumor of injected mice was observed. These results demonstrate that the CCTS nanocrystals could be the promising MRI theranostic nano-agents and have a great application prospect.