喉頭アレルギーに対するＩＰＤの効果

Abstract

Twenty-three patients with an allergy of the larynx, who complained of a foreign body sensation in the throat or a persistent cough, inclusive of eight suspected patients, were treated with suplatast tosilate (IPD) for an average of 36.3-24.0 days between January 1997 and December 1999. The final subjective efficacy of IPD (300 mg/day) in twenty evaluable patients were as follows: excellent, 50.0%; good, 40.0% ; and poor, 10.0%, with an efficacy rate of 90.0%. The final subjective effectiveness rates inclusive of excellent and good efficacy were 90.9% for the IPD® single administration group, and 88.9% for the combined administration (IPD®+concomitant drugs) group. No statistical differences in efficacy were noted between the two groups. Mild nausea appeared as an adverse effect in one patient (4.8%) in the IPD single administration group. It was speculated that the efficacy of IPD therapy for the allergy of the larynx is mainly attributable to suppression of chemical mediators derived from mast cells of the laryngeal mucosa or suppression of IL-4 or IL-5 production from The type cells.