Abstract
Fatty acid oxidation activities in brain microvessels of spontaneously hypertensive rats (SHR) were decreased with persistent of hypertension, which is closely related to the formation of angionecrosis. Pantethine restored this decrease of fatty acid oxidation activities in vivo. Mechanism of this activating effect of pantethine was investigated in liver mitochondria and brain microvessels.Pantethine, pantetheine and 4′-phosphopantetheine activated three steps of fatty acid oxidation, that is, acyl-CoA formation, acyl-CoA incorporation into mitochondria (carnitine acyltransferase) and intramitochondrial oxidation, 4′-phosphopantetheine being most effective.For these incubations, pantethine was metabolized to pantetheine, 4′-phosphopantetheine, dephospho-CoA and coenzyme A, and the amount of 4′-phosphopantetheine was most and that of CoA was least, suggesting that the activating effect of pantethine on fatty acid oxidation may be mainly due to 4′-phosphopantetheine.Pantethine increased phospholipid synthesis in brain microvessels of SHR with activation of fatty acid oxidation on both aerobic and anaerobic conditions. This effect might be a mechanism of activating effect of pantethine on fatty acid oxidation.
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