糖尿病における高脂血症の病態生理に関する研究

Abstract

Serum apolipoprotein and lipid levels have been studied in type 2 diabetic subjects.1) In type 2 diabetic subjects, apo A-I, A-II, B, C-II, E are all significantly elevated compaired with that in control subjects.2) Positive correlation was observed between apo A-I and FPG level.3) Apo B level was correlated with total cholesterol, TG and LDL-Chol level. The elevation of apo B levels was also observed in subjects with normolipidemia and therefore serum apo B level seems to be an important marker for deranged lipid metabolism.4) Apo C-II level was correlated with TG level, but not with T. chol level, and it did not increase in those with insulin therapy. Thus, the elevation of Apo C-II level seemed to be secondary to the elevation of serum TG level.5) App E level was correlated with T, chol as well as TG levels, and it did not increase in normolipidemic subjects. This suggests that the elevation of apo E level is also secondary to the elevation of serum T.chol and TG level.In type 2 diabetic subjects serum levels of apoprotein were all elevated. Since apo C-II & E were normalized in those on insulin treated, while elevation was noted for serum apo B level, changes of apo A-I & B level may serve as an metabolic and atherogenic marker.