メニエール病およびメニエール病類似疾患に対する抗うん剤薬効の検討

Abstract

Ifenprodil, cinnarizine, and low molecular weight dextran (250ml) were administered to patients with Meniere's disease (typical and atypical types), and their effectiveness and side effects were evaluated. Ifenprodil was administered to 50 patients, 32 of whom had had diphenidol previously. In all of the 50 patients, who were observed on an average of 161 days, the rate of most effective was 40%.The antivertiginous effect of cinnarizine was evaluated in a single administration to 38 patients with Meniere's diseas (typical and atypical types), who were observed at a mean of 105 days, the rate of most effective was 42%.In 30 admitted or readmitted patients with Meniere's disease (typical and atypical types), the effect of low molecular weight dextran (250ml) was evaluated.The rate of most effective was 40%, which was mainly observed in improvement in hearing difficulty in sudden sensoneural hearing loss or Meniere's disease.Good effects were seen from all three drugs in patients with vestibular disorder with an apparent dysfunction of the central nervous system as reflected in the eye-tracking test and examination for optokinetic nystagmus.