Abstract
The saccharine test was used to measure nasal mucociliary clearance in 71 patients with nasal allergy (56 without and 15 with chronic sinusitis), 12 patients with asthma (7 without and 5 with chronic sinusitis) and 7 patients with aspirin-induced asthma. The results were compared with those of a control group of 15 healthy subjects. The saccharine time (ST) in patients with nasal allergy without chronic sinusitis (16.9±9.9min) and in those with asthma without chronic sinusitis (20.1±9.4min) did not differ not significantly from that in the healthy subjects (16.3±5.3mm). But the ST in patients with nasal allergy and chronic sinusitis (37.6±22.9min) and in those with asthma and chronic sinusitis (57.0±6.7min) was significantry longr than in the controls (p<0.01). The ST in aspirin induced asthma (13.0±5.4min) was not higher than the ST in the control group. These results suggest that allergic reactions in patients with allergic diseases do not affect nasal mucociliary clearance and that the nature of the mucus and the relationship between ciliary movement and the mucus layer are important in nasal mucociliary clearance.
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