上顎歯肉癌患者にみられた頚部リンパ節炎型トキソプラズマ症の１例

Abstract

We report a case of lymphadenitis type toxoplasmosis in the submandibular and cervical lymph nodes of a 53-year-old man with squamous cell carcinoma of the upper gingiva at the right side of the upper incisor region. The size of the tumor was 18×14mm. The patient had swelling of multiple lymph nodes in both sides of the submandibular region and the right side of the cervical region. Tumor resection with neck dissection was performed after chemotherapy with a combination of 5-fluorouracil and cisplatin. Histopathological specimens prepared from the dissected lymph nodes showed no metastatic lesions, but the lymph node specimens had increased numbers of lymphoid follicles, monocytoid B lymphocyte aggregation in the sinus or parafollicular area, and epithelioid cell clusters, especially in the germinal centers. Since these findings strongly suggested toxoplasmic lymphadenitis, serological examination was performed, and an increased level of serum toxoplasmic antibody was detected. In conclusion, we diagnosed this case as toxoplasmic lymphadenitis in the regional lymph nodes associated with squamous cell carcinoma of the upper gingiva.