体外循環を使用した胎児心臓手術開発の現状と可能性

Abstract

e use of cardiopulmonary bypass during surgery is the most challenging procedure in all the possible fetal cardiac interventions. Catheter-based fetal cardiac interventions have recently been developed and applied in the clinical setting for a particular category of congenital heart diseases. e intention was to improve long-term results by allowing the heart to grow normally before birth. However, the procedures that can be performed using catheter intervention are very limited, the primary examples of which are atrial septostomy, aortic valvotomy, and pulmonary valvotomy. ere is still a group of congenital heart diseases, such as total anomalous pulmonary venous connection, hypoplastic le heart syndrome, pulmonary atresia with intact ventricular septum, and Ebstein’s anomaly, for which long-term results could be improved or Fontan circulation could be avoided using fetal surgical cardiac intervention but may not be achieved using catheter intervention. In 1985, Richter et al rst reported an animal study on fetal cardiopulmonary bypass. Since this report, which was over 30 years ago, several developments in this eld have been achieved; however, there are no case reports on successful fetal cardiopulmonary bypass in humans. e aim of this study was to determine the current status of developments in fetal surgical intervention using cardiopulmonary bypass.