Abstract
In order to elucidate the relation between intraglomerular fibrin deposition and types of serum and urinary fibrin/fibrinogen degradation products (FDP) in children with various renal diseases, the extent and distribution of fibrinogen related antigen (FRA) deposition in the kidney tissue which was perfesed with monochloacetic acid (MCA) solution was examind by immunofluorescent microscopy in comparison with deposition of factor XIII subunit-A (XIII-a). In addition to the immunofluorescent studies, the typing of FDP was made by SDS polyacryamide gel electrophoresis and crossed immunoelectrophoresis (SDS-PAGE-CIE).Intrarenal deposition of FRA after MCA treatment was observed mainly within the glomerular capillary walls, mesangium or vessels, and its extent and distribution showed a good agreement with that of XIII-a. Patterns of SDS-PAGE-CIE of MCA insoluble FRA products by plasmin were similar to those seen in cross-linked fibrin. These findings suggest that MCA insoluble FRA or XIII-a deposition reflects the extent and distribution of cross-linked fibrin.The presence of D-dimer in the urinary FDP was well seen in the children who had intrarenal fibrin deposition.
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