Abstract
Topical medicinal substances (or drugs) in liquid formulations are conventionally applied using cotton, gauze or other applicators made of cellulose materials. The adsorption of drugs by these cellulose materials is known to reduce the availability and, therefore, the efficacy of such drugs for patient treatment. In our previous studies, cellulose fibers were found to be negatively charged. A substantial degree of adsorption of positively charged or cationic drugs, such as disinfectants, due to electrostatic interaction was also observed in these studies. The objective of this study was thus to determine the effect of coating cottonwith positively charged chitosan on cationic drug adsorption. The results of this study indicate that coating cotton with chitosan reduces the adsorption of cationic drugs in the application of topical formulations.
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