膀胱癌化学療法についての研究

Abstract

Five cases of bladder cancer were treated with continuous infusion of Mitomycin C into the internal iliac artery. The histological changes of the cancer cells and DNA content in nucleus were studied.1) No relationship between histological malignancy and DNA content was found.2) In four cases, decrease of DNA content with diminition in the range of DNA distribution and shift of the peak to the left was noted after the administration of Mitomycin C in the amount of 70-80mg.3) Histological changes did not always parallel to changes of the DNA content.Histological changes and DNA content in nucleus of canine bladder epithelium were studied in four groups administered 1mg/kg of Mitomycin C as follows, Group 1. Systemic administrationGroup 2. One shot injection into the internal iliac arteryGroup 3. Infusion into the lumen of the urinary bladderGroup 4. Continuous injection into the internal iliac artery1) No definite morphological changes were shown in groups 1 and 2, whereas atrophy, flattening and exfoliation of epithelial cells were revealed in groups 3 and 4.2) DNA content in the nucleus of epithelial cells showed no changes in groups 1, 2 and 3 but decreased in group 4.