Abstract
We carried out immunohistochemical studies of granulation tissue adjacent to the Cholesteatoma sac using both polyclonal antibody against keratin and monoclonal antibodies against lymphocyte subsets. Keratin (debris) was frequently associated with giant cells, macrophages and lymphocytes infiltration, forming a so-called keratin granuloma. In patients with clinically active cholesteatoma, many such keratin granulomas were identified. The lymphocytes surrounding the keratin were mainly T lymphocytes, mostly cytotoxic/suppressor cells. These results suggest that immune responses against keratin (debris) play an important role in the pathogenesis of choles-teatoma and accompanying bone resorption.
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