輸血によって産生された抗ｆ抗体の一症例

Abstract

We experienced a case of anti-f antibodies in a patient with a history of blood transfusion. The patient was a 54-year-old Japanese man with an alcoholic psychosis who received three red blood cell transfusions for the treatment of anemia from November 22, 2001 to January 18, 2002. During this period, his serum was screened twice, and no immune antibodies were detected. Prior to a subsequent fourth transfusion, anti-f antibodies were detected in his serum on a third screening. The titers were ×2 by the Bromelin method, and ×4 by the Coombs method, showing a dosage effect which is characteristic of Rh blood groups. At the same time, his direct antiglobulin test was positive, but there was no evidence of clinical hemolysis. After detection he received a single transfusion of compatible blood with good effect. This case emphasizes the importance of regular antibody screening in patients receiving multiple transfusions of red blood cells.