Abstract
Two cases of patients with multiple primary cancers involving the larynx and the oral floor are reported.Case 1: A 64-year-old male complaining of hoarseness was diagnosed as having laryngeal cancer (supraglottis T1aN0M0), for which horizontal partial laryngectomy was performed. About one year after the operation, he was diagnosed as having oral floor cancer (T1N0) and treated by Lineac and chemotherapy. He had third primary esophageal cancer, treated with irradiation but died without cancer recurrence in the larynx or oral floor.Case 2: A 56-year-old male complained of hoarseness and was diagnosed as having laryngeal cancer (glottis T3N0M0) and treated by total laryngectomy. About one year after the operation, he was diagnosed as having oral floor cancer (T1N0) and treated by irradiation. This tumor mass did not decrease in size and be received an operation. He is at present under observation. Pathologically, these three cancers were squamous cell carcinoma.These patients were heavy smokers and heavy drinkers. The first case was considered as field carcinogenesis.The effect of joint exposure to tobacco and alcohol are discussed.
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