腹膜播種患者に対するタキサン系抗癌剤の腹腔内投与時における腹水および血しょう中濃度推移

Abstract

We evaluated the disposition kinetics of taxanes, an antitumor agent after the intraperitoneal administration in nine patients with peritoneal tumors. The intraperitoneal concentrations of docetaxel or paclitaxel decreased slowly following the i.p. infusion administration of either docetaxel (60-80mg/day) or paclitaxel (120-180mg/ day) over a 1-hour period in patients. There was no difference in the concentration-time courses between both drugs in each patient, and the elimination half-time was about 8hr. The area under the intraperitoneal concentration-time curve (AUCp) of paclitaxel relative to the dose was about 3-times larger than that of docetaxel. On the other hand, the permeability of these drugs from the peritoneal cavity into the systemic circula-tion was extremely small. The plasma concentrations and the AUCs of both drugs showed large individual variations among the patients. The ratios of AUCs/AUCp of docetaxel and paclitaxel relative to the dose were 7.1 ×10-2and 3.8×10-3, respectively. The permeability of paclitaxel was only about 1/20 that of docetaxel.