進行喉頭癌に対する超選択的動注化学放射線療法の効果

Abstract

Sixteen patients with advanced laryngeal cancer were treated between 1999 and 2004 with intra-arterial infusion of cisplatin at 64-100mg/m2 and intravenous infusion of sodium thiosulfate (P regimen). For the patients who had received the PF regimen, 5-fluorouracil (5-FU) at 700 mg/m2 was given for 3 days following intra-arterial administration of CDDP. With the patients who had underwent the TP regimen, docetaxel at 10-20 mg/m2 was intra-arterially administered following intra-arterial administration of CDDP. All patients received radiation (50-70Gy). Seven patients were at the T3 stage, nine patients at T4, eight patients had glottic cancer and eight patients had supraglottic cancer. The complete response rates of the primary sites that were achieved were 80% for the P regimen, 50% for the PF regimen, and 100% for the TP regimen. The 5-year overall survival rate and disease specific survival rate of all cases was 58% and 81% respectively. The 5-year laryngeal preservation rates were 53% for the P regimen, below 25% for the PF regimen, and 80% with the TP regimen. Side effects of this treatment were tolerable, with the exception of individual cases of cerebral infarction, neck skin necrosis, and laryngeal necrosis.