Abstract
Earlier epidemiological studies have suggested a link between the increase in atomospheric pollutans and increases in the incidence and morbidity of allergic airway disease. The hallmark of these disease is an increase in the production of IgE. Diesel exhaust particles (DEPs) have been implicated in the increased incidence of allergic airway disorders among Japanese. We show that an extract of polyaromatic hydrocarbons from DEPs enhances human IgE production in purified B cells. The enhancement of the effects of DEPs on localized immunoglobulin production was demonstrated by performing nasal challenges with varying doses of DEP. These studies show that natural exposure to DEP may result in increased expression of respiratory allergic disease including Japanese cedar pollinosis and asthma.
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