水溶液中におけるアダマンタンカルボン酸イオンとの包接化合物形成によるシクロデキストリンの溶解度変化

Abstract

Solubility (30mg.cm-3) of α-cyclodextrin in water at pH7 and 30°C in the presence of the equimolar amount of adamantane-1-carboxylate [1] is much smaller than that (170mg.cm-3) in the absence of 1. In contrast, solubility of β-cyclodextrin (65mg.cm-3)in the presence of [1] is larger than that (21mg.cm-3) in the absence of 1. The enhancement of solubility of β-cyclodextrin by [1] is ascribed to the conformational change of β-cyclodextrin by the inclusion of bulky [1] into its cavity, which promotes the interactions between the hydroxyl groups of β-cyclodextrin and the solvent water molecules.