副腎剔出後及び脳下垂体剔出後の胃潰瘍発生に関する実験的研究

Abstract

I. Serum Elecurolytes and Blood Glucose in the Development of Gastric Ulcer Following HypophyseoadrenalectomyCombining the adrenalectomy with the hypophysectomy, the ulceration of gastric mucosa was also observed, accompanied by hyponatremia, hyperpotassemia and hypoglycemia.Making correction of this abnormalities with intramuscular application of cortisone (0.1 mg., per 100 gm. of body weight, per day) simultaneously with oral intake of 5% glucose solution, the ulceration was remakably inhibited, whereas administration of 1% saline alone failed to correct the electrolyte unbalance and to inhibit subsequent ulcer formation.II. Influence of Vagotomy in the Development of Gastric Ulcer Following Adrenalectomy and HypophysectomyBilateral vagotomy supressed the causation of the previously mentioned abnormalities in the serum electrolytes and the fluctuation of blood sugar level and also surpressed the development of gastric ulcer, following the adrenalectomy and hypophyseoadrenalectomy.The effect of the right vagotomy on this supression was predominant over the left vagotomy.In summary, these results are highly indicative of the presence of some direct or indirect relationship between the unbalanced serum electrolytes and blcod glucose level due to àdrenal deficiency and the deterioration in the lccal resistance of gastric mucosa against the digestive process to develop subsequent ulceration.Association of vagal nerve in the mechanism of this type of gastric ulcerogenesis was also demonstrated.