Abstract
The clinical efficacy of erythromycin, clarithromycin (CAM) and roxithromycin on chronic paranasal sinusitis has been reported in numerous studies. We investigated the clinical efficacy of low-dose and long-term CAM on sinusitis in children. Each child was given 5-7mg/kg of CAM as two doses daily. The clinical efficacy was assessed by the quality and quantity of nasal discharge, and by the findings on plain X-ray films of the maxillary sinuses after 8 weeks of administration. Twenty-one out of 28 (75%) patients treated with CAM demonstrated an improvement in the quality of nasal discharge. Twenty out of 28 (71%) patients treated with CAM demonstrated an improvement in the quantity of nasal discharge. Twenty-four out of 28 (86%) patients treated with CAM demonstrated an improvement in their findings on plain X-ray films of their maxillary sinuses. Patients who received CAM demonstrated significantly better quality and quantity of nasal discharge, and their findings on plain X-ray films of their maxillary sinuses were better than patients who didn't receive CAM. Clarithromycin was judged to be useful in the treatment of sinusitis in children.
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