Abstract
The measurement of pressure in the scala media during impaired hearing is of interest, because pressure changes may occur during attacks of vertigo in Meniere's disease.In this study, the changes of cochlear pressure and cochlear microphonics (CM), while acute pressure was applied to the scala media, were examined in 10 guinea pigs.Artificial endolymph was injected into the scala media (SM), and the endocochlear potential (EP) and CM were recorded simultaneously from an electrode within the scala media. Into another small hole opened in the scala vestibuli, a glass electrode was introduced to measure the pressure of the cochlear fluid by a WPI pressure measuring system.Apnea induced a decrease of EP & CM and increase of cochlear lymphatic pressure. This pressure had no direct relation to the decrease of EP & CM. When the pressure was applied to the scala media, the decrease of CM occurred exponentially.The lowest pressure applied, combined with complete disappearance of CM, was 2.4 mm H2O. This means that the CM generating system is completely destroyed by a pressure of 2.4 mm H2O.
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