Abstract
New strategy of lipase-catalyzed asymmetric reactions is described. Chiral 2-O-substituted glycerols, 2-substituted 1, 3-propanediols and 1, 4-diols were obtained in high optical yields by the asymmetric transesterification using activated esters as acyl donors. Facile process for the kinetic resolution of racemic alcohols was developed by the lipase-catalyzed esterification with acid anhydride. And chiral 1, 4-dihydropyridines and barbiturates were obtained in high optical yields by the lipase-catalyzed hydrolysis of their acyloxymethyl groups. Chiral medicines were synthesized from optically active compounds obtained by these lipase-catalayzed asymmetric reactions.
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