Abstract
In this study, to reconstruct the jaw defect site, a hybrid substance consistingof Polyelectrolyte Complex (PEC) and Hydroxyapatite (HA) was prepared, and a prosthesis with this substance was fabricated in the mandible of adult dogs. Two types of HA with 500 μm or 1, 000 μm in particle diameter and a pore rate of 35% or more were used. The animals consisted of 12 male Beagles. As for PEC, polycation (S-110) and polyanion (S-chitin 140), which show favorable cellular adhesiveness and cell proliferation, were used. The rate and amount of bone formation in the PEC-HA Hybrid group were significantly higher than those in the controlgroup, the PEC group and the granule group.The results suggested that PEC-HAHybrid can be clinically used as a biomaterial that may shorten the period required for bone formation and increase the amount of neogenetic bone.
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