Abstract
H. M. G. cell strained from the tumor cell in the pleural fluid of a patient with malignant melanoma was transplanted in a nude mouse and the tumor formed was given various drugs to examine their respective effects macroscopically, light-and electron microscopically.Drugs used are MPL, DTIC, TA-077 and CDDP as alkylating agent, FT-207 as metabolic antagonist and PSK as immunological preparation. These drugs were administered singly or combinedly (MPL+TA-077, CDDP+MPL, DTIC+FT-207 and PSK+MPL). MPL, TA-077 and CDDP showed tumoristatic effect and MPL-F TA-077 and CDDP+MPL, tumor retracting effect. PSK+MPL showed greater effect compared with single administration. However, none of the other drugs had any tumoristatic effect, with no great difference from the control.In terms of the fine structure, some changes were observed in the nucleus and intracellular organelle; specific change in mitochondria and characteristic appearance of intranuclear corpuscle were seen with CDDP and with MPL+TA-077 and CDDP+MPL, respectively.Tumor cell became larger and smaller with CDDP, MPL+TA-077 and CDDP+MPL and with TA-077, PSK and PSK+ MPL, respectively.These changes proved to be related obviously to the antitumor effect.
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