Abstract
We studied the clinical effectiveness of Lipo-prostaglandin E1 (Lipo-PGE1), which has vasodilating activity on microvessels and anti-platelet properties, in patients with sudden deafness. Fifty-five patients were treated with steroids (group I ) and forty-three patients were treated with Lipo-PGE1 plus steroids (group II). In group I, 10 patients (18.2%) presented with a complete recovery, 9 patients (16.4%) presented with a marked improvement, 20 patients (36.4%) presented with an improvement and 16 patients (29.1%) presented with no change. In group II, 19 patients (44.2%) presented with a complete recovery, 4 patients (9.3%) presented with a marked improvement, 9 patients (20.9%) presented with an improvement and 11 patients (25.6%) presented with no change. It was concluded that combined therapy with steroids plus Lipo-PGE1 was more effective in patients with sudden deafness, especially in severe cases.
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