Abstract
1. P-MeC (containing 10mg/kg of MeC) was injected intramuscularly into two suckling piglets. The blood levels (unit:μg per ml of serum) determined in the two animals at certain intervals of time after injection were 28.0 and 30.6 at 1 hour, 19.0 and 16.0 at 4 hours, 14.5 and 16.0 at 6 hours, and 2.35 and 2.85 at 24 hours.2. In normal healthy piglets, the average value of Escherichia coliwas 9.20 at 1 week of age, 8.84 at 2 weeks, 8.04 at 3 weeks, 8. 15 at 4 weeks, 7.31 at 5 weeks, and 8.60 at 6 weeks. In piglets suffering from diarrhea, it was in a range of 6.78 to 12.18, averaging 10.30.3. The growth of E. coli organisms derived from the feces of the piglets affected with diarrhea was inhibited to a considerable extent in SLSHI medium to which P-MeC and MeC-sensitive disks had been added.4. A total of 105 cases of diarrhea in suckling piglets were effectively treated with P-MeC (containing about 1.26 to 7.08mg/kg of MeC) administered by the intramuscular route.5. No side-effect was observed in any piglet treated.
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