Abstract
1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride (Y-6124) inhibited at each dose of 50, 100 or 500μg/kg administered intravenously arrhythmia induced by rapid intravenous injection of 10μg/kg epinephrine in dogs anesthetized with sodium secobarbital, or arrhythmia induced by continuous infusion of 5μg/kg/ min epinephrine into the vein of a dog anesthetized with fluothane. Y-6124 and propranolol inhibited these epinephrine-induced arrhythmias at the almost the same dose as that of its β-blocking action. Y-6124 inhibited arrhythmia induced by continuous intravenous infusion of 5μg/kg/min ouabain in anesthetized dogs at a dose of 2.5 or 5mg/kg i. v., but did not change the lethal dose of ouabain in dogs. Propranolol inhibited arrhythmia and increased the lethal dose of ouabain in dogs. Y-6124 had a therapeutic effect on arrhythmia induced by intermittent and cumulative administration of ouabain at a dose of 2.5mg/kg i. v. or more. Potency was almost the same as that of propranolol.
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