八丈島におけるアポ蛋白動態

Abstract

Previously we have reported that the rate of cerebral vascular disorders as well as the cases of severe hypertension in old ages are significantly less in Hachijo island than in the whole country.We have also examined the serum eicosapentaenoic acid (EPA), EPA/AA ratio and platelet aggregation in the groups eating fish well and seldom (the group eating fish well represents those eating fish at every meal), and found that the group eating fish well had high concentration of EPA, high EPA/AA ratio and diminished platelet aggregation.In this paper we attempted quantitative examination of apolipoproteins of the habitants in Hachijo island. Blood samples, obtained from 45 subjects, 25 male and 21 female subjects, were analyzed. Apolipoproteins (Apo A-I, Apo A-II, Apo C-II and Apo E) were estimated by the method of Single Radical Immunodiffusion (SRID). Apo C-II in male was significantly higher than that in female. Apo A-I and apo A-II in the group of obesity were higher than those in nonobesity. There was no significant difference in the composition of apolipoproteins between the group of smoking and non-smoking, while apo A-I and apo A-II in the group of drinking were significantly higher than those in the non-drinking group. A-I/A-II ratio in the group eating fish well was higher than that in the no fish group. Significant correlation were found among the values of serum total cholesterol, triglyceride and apo E, apo C-II.