フルオレセインナトリウムと標準手技チェックリストを用いた抗がん剤調製実技講習

Abstract

Since anticancer agents are toxic,their preparation requires the attending pharmacist to have a high level of technical skill to avoid contamination from them.We conducted an educational program which taught the preparation of anticancer agents using fluorescein sodium (FL) as a placebo and a standard procedure-list for 15 persons who had either had no experience of preparation or less than 1 year’s experience.FL was chosen as contamination due to it could be detected under UV and the standard checklist was designed to aid confirmation that the standard procedure was being followed in preparation.In the program,after 1 try at preparation,there was 30 minutes of self study and then participants tried preparing the placebo anticancer agent again by the same procedure.The number of FL spots detected under UV,time for preparation,and score for preparation according to the checklist was compared between the 2 tries at preparation,and additional information was obtained using a questionnaire.As for the results,the number of FL spots detected under UV decreased significantly from 2.3±0.4 to 1.1±0.2 (p= 0.018),the preparation technique score significantly increased from 13.9±1.1 to 17.9±1.0 (p=0.002)and time for preparation decreased from 13.0±1.3 min.to 10.2±0.9 min.(p<0.0001).Additional information obtained through the questionnaire indicated that the participants felt satisfied with the program.In conclusion,we feel that this program is highly beneficial in training on the preparation of anticancer agents.