サルにおける赤痢菌感染実験について

Abstract

This experiment was made for the purpose of comparing with administrations of report I (on the clinical and pathological observations in the monkies introduced with dysentery bacilli into the stomach and the intestinal lumen), III (on the clinical and pathological observtions in the monkies introduced with dysentery bacilli into the stomach after pretreatment: oral administrations of sonicate of dysentery bacilli or chloramphenicol) and IV (on the clinical and pathological observations in the monkies introduced with dysentery bacilli into the stomach after the starvation for 2 to 3 days).6 monkies (M.irus) weighing 2 to 3kg were used in this work.Those which were starved were deprived of food for 2 to 3 days before oral administration of living cultures (10×1010 to 17×1010 cells).The results were as follows:In 5 of 6 animals challenged, symptoms of acute bacillary dysentery were observed and the symptoms were closely resembled to those of acute bacillary dysentery which are seen in human beings.They produced clinical and pathological observations similar to those described in the reports I and III.The organisms were found throughout the length of the intestinal tract.Gastritis and colitis with the hemorrhage were recognized.