Abstract
To evaluate the effects of switching from NPH insulin(twice daily)to insulin glargine on blood glucose control(HbA1C),insulin dosage and frequency of hypoglycemia in Japanese patients with type 1 diabetes,we monitored these parameters in 37 type 1 diabetics for 12 months after switching.The patients were assigned to 3 groups according to HbA1C at switching :good(<7.0%),fair(7.0-7.9%)and poor(≥8.0%).Though there was no improvement in HbA1C in the good and fair groups over the 12 months,there was a significant decrease in HbA1C in the poor group(10.2±1.2%→9.2±1.2%,p<0.01).Over this period,total dosage and basal dosage significantly decreased as compared to the time of switching.In the good and poor control groups,there was a significant decrease in the frequency of hypoglycemia.In conclusion,insuling largine improves glycemic control in patients with type 1 diabetes mellitus,especially in patients with poor blood glucose control.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
