コレステロール負荷ウサギの血中脂質ならびに副腎機能に及ぼすたばこ煙吸入の影響

Abstract

Rabbits were given cholesterol (CH) (1.5% CH supplemented diet ad libitum) and tobacco smoke (inhalation of smoke from 5mm length cigarette with or without glass fiber filter, two times a day), separately or in combination, for 4 weeks.Plasma HDL-CH levels in CH fed rabbits elevated in first two weeks then lowered gradually, while total CH, TG, and FFA increased significantly towards the end of experiment. Those increases in blood lipids by CH diet were inhibited by tobacco smoke inhalation, and especially by filtered smoke increase in atherogenic index (A. I) was only slight. Inhalations of both kinds of smoke induced a significant decrease in HDL after 2 weeks and increases in CH and A. I after 4 weeks.Corticoids (CD) in blood increased in CH fed rabbits either with or without tobacco smoke inhalation but showed no change in rabbits given tobacco smoke alone. As the adrenal weight increased by the CH diet, adrenal CS level per weight was lower in CH fed group, but total CS content in adrenals was not affected by CH diet.Adrenaline content increased both in blood and adrenals by both kinds of tobacco smoke seemed to be lowered. CH diet inhibited the increment of adrenaline (A) in adrenals. Noradrenaline (NA) increased only in adrenals of rabbits inhalated tobacco smoke.In summary, increases in blood lipids, blood and adrenal (A). and adrenal (NA) were resulted by tobacco smoke inhalation. Simultaneous application of CH diet inhibited the increase in blood lipids, however the mechanism of this combined effect was left for further researches.