Abstract
The gonadotropin levels following castration, exogenous estrogen and testosterone administration were studied in human males.Serum LH and FSH levels were measured by radioimmunoassay in patients with prostatic canter following castration and estrogen therapy. Effects of testosterone on gonadotropins were examined in patients with Klinefelter's syndrome recieving androgen replacement therapy.1. After the castration, serum LH and FSH levels increased gradually in all six patients, and reached levels 3.5, 2.6 times higher than previous values at 7th postoperative day, respectively.2. Administration of estrogen (Diethylstilbestrol diphosphate) suppressed both LH and FSH. FSH levels were more easily suppressed than LH levels. The doses of estrogen required to suppress the gonadotropins to the lowest level were about 30 to 60mg/day for DES-diphosphate and 10 to 30mg/day for Hexestrol.3. By the administration of testosterone propionate (25-100mg. im.), LH levels were markedly suppressed. FSH levels were also suppressed but not so marked as LH levels.
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