血管柄付き異所性骨片への仮骨延長法の応用に関する実験的研究

Abstract

Autogenous bone remains the most suitable material for bone grafts used to repair oral and maxillof acial bone defects. However, there are restrictions on the use of autogenous bone grafts at donor sites. In a previous study, we produced a prefabricated bone graft with the use of autologous vessels and auto-cancellous bone. In this study, we examined the usefulness of distraction osteogenesis for increasing bone associated with prefabricated bone grafts.We placed ectopic bone grafts in the limbs of rats and fixed an originally designed distraction device to the ectopic bone after 9 weeks. Distraction was started 3 days after the second operation. After 1, 2, 3, and 6 weeks of distraction, radiographic and histological analyses were performed to observe osteogenesis. As control, undistracted ectopic bones in rats of the same age were similarly studied.Our results show that distraction osteogenesis is useful for quantitatively increasing bone associated with grafts.