Abstract
A new designing concept, "Respective Control Concept, "for developing highly efficient chiral bisphosphines ligands has been proposed. On the basis of our concept, new chiral bisphosphine ligands, BCPM, MCCPM, MOD-BPPM, MOD-DIOP, MOD-Degphos, MOC-BIMOP, Cy-BIMOP, etc., have been synthesized. Their rodium complexes have been formed and found to show high catalytic activity and enantioselectivity in the asymmetric hydrogenation of prochiral carbonyl and olefinic compounds leading to the practical synthesis of chiral aminoalcohols, α-amino acid derivatives and succinic acid derivatives. Furthermore, asymmetric synthesis of chiral 1, 4-dihydropyridines, barbiturates, and glycerol derivatives was realized using lipase-catalyzed reactions in organic solvents. The lipase PS mutant (FVL) was indicated to show the same hydrolytic behavior as that of lipase AH.
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