頭けい部悪性しゅよう患者の非特異的免疫能

Abstract

We studied the following nonspecific humoral and cellular immunologicai factors in 240 patients with head and neck malignant tumor. On humoral factors; serum globulin, serum immunoglobulin, complement, CEA and serum immunosuppressive factor, on cellular factors; CellS of blood lymphocyte, percentage of T, B and IgG•FcR+T lymphocyte, skin reaction to PPD and PHA, MIF and PHA-induced lymphocyte transformation. These patients have already had abnormal immunological conditions compared with control non-malignant tumor subjects before treatment. Of humoral factors, serum α1, α2, γ globulin, complement and immunosuppressive factor were significantly elevated. Of the cellular factors, the number of blood lymphocyte was depressed. However, no significant difference was found in other factors.To elucidate the influence of histological character of tumor, stage of disease, age of patients and method of treatments on the immunological conditions, the patients were examined by the following five tests; serum α2 globulin, serum immunosuppressive factor, cells of blood lymphocyte, PHA skin test and PHA-induced lymphocyte transformation. 1) Patients with maxillary cancer or malignant lymphoma showed remarkably significant elevation of the humoral factors and depression of the cellular factors. 2) In the patients with advanced tumor, all humoral faceors were elevated and the cellular factors were depressed in the majority of patients. 3) Depressive tendency to the cellular factors was remarkably observed with aging. 4) Although the humoral factors were elevated, the cellular factors remained unchanged after the operation. While the humoral factors were unchanged, the cellular factors were depressed after the irradiation.