Abstract
Aspergillosis, a fungal infection generally acquired by inhaling airborne spores (conidia) of the ubiquitous mold Aspergillus, may cause symptomatic infection such as allergic aspergillosis in young atopic subjects, aspergillomas also called fungus balls, and invasive aspergillosis typically seen in debilitated or immunocompromised subjects. A 71-year-old man who had undergone chemoradiotherapy for malignant lymphoma 12 years earlier was seen for a visual disorder and pain. It was found in computed tomography (CT) and magnetic resonance imaging (MRI) to have a right orbital apex lesion but no paranasal sinus abnormalities. Based on a diagnosis of optic neuritis without a histopathological diagnosis, we started systemic steroid therapy, which only worsened his symptoms. Endoscopic endonasal orbital apex biopsy conducted afterwards for a definitive diagnosis found that the visual disorder was caused by invasive fungal infection, underscoring the importance of pathological examination.
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