簡易懸濁法におけるグラマリール細粒およびポンタールカプセルの主薬溶出性の検討

Abstract

The simple suspension method is a recently developed technique for the administration of tablets or capsules by tube.The drugs in their original dosage forms are directly suspended in hot water (55°C) so that they can be delivered through a tube.In the present study,we evaluated the recovery of drugs regarded as unsuitable for the simple suspension method.After fine granules of Gramalil® and its generic equivalents had been put in syringes to make suspensions in hot water,tiapride hydrochloride was mainly detected in the suspensions forced out of the syringes,suggesting that it would be possible to conduct tube administration by this method.However,when the suspensions were prepared in cups,the amount of tiapride hydrochloride to be administered was found to vary,indicating that this method was unsuitable for conducting the tube administration of Gramalil® and its generic equivalents.On the other hand,making suspensions of the contents of Pontal® capsules by either of the above 2 methods was found to be unsuitable for tube administration because the recovery of mefenamic acid was consistently low,though the findings for making suspensions of Pontal® tablets in a syringe suggested that tube administration by this method would be feasible.The results of the present study indicated that if residues are observed on administering these drugs by tube using the simple suspension method,the amount of drug actually administered to a patient depended largely on its water solubility and the types of additives used.