Abstract
The deposition of immune complexes was investigated in various stages of experimental gingivitis by immunofluorescence.After the bimaxillary premolars of beagle dogs were brushed for 1 month to obtain a clinically healthy gingiva, the experimental gingivitis was induced by plaque accumulation following ligature with floss silk. The gingival biopsy specimens were obtained at 0 day, 1 week, 1 month and 3 months after the start of plaque accumulation. The localization of immunoglobulins (Ig), complement (C3) and anti-plaque antibody (Ab) was compared in these specimens, untreated and treated with PBS or citrate buffer using immunofluorescent antibody and antigen techniques.The following findings were obtained:The localization of C3 increased with times to the maximum level 1 month postoperatively, resulting in a plateau at 3 month postoperative periods and IgM and Ab localized in a similar fashion. Therefore this finding reflects a presence of immune complexes. However, since a large majority of Ig, C3 and Ab localized in early and established lesions were washed out with PBS, not indicating that the immune complexes deposited in a tightly fixed state.
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Schedule a callMore From: Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)
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