フィブロネクチン含有人工滑液における豚関節骨頭の摩擦振動特性に関する基礎研究

Abstract

The purpose of this paper is to determine experimentally the fundamental data of the new artificial synovial fluid, which suppressed the use of sodium hyaluronate (HA). Consequently, a fundamental study is carried out using fibronectin (FN), which is the cell-adhesive proteins that exists in human blood and synovial fluid. The new artificial synovial fluid consisted of FN, dipalmitoyl phosphatidylcholine (DPPC), HA and isotonic sodium chloride solution (I.S.C.S.) as solvent. An evaluation of new artificial synovial fluid is employed by the friction tester with reciprocating slider. In order to verify from an engineering standpoint, the evaluated items are the total amount of wear between the cartilage on articular head of pig joints and the ultra high molecular weight polyethylene (UHMWPE) socket; and the amplitude of vibration which is analyzed with FFT at 80Hz, the resonant frequency of the movable portion in the friction tester. The results indicated that the artificial synovial fluid containing FN was effective in the reduction of the total amount of wear and the amplitude of vibration. Further, it turned out that the effect of vibrational reduction was better than the effect of wear reduction if FN is added to artificial synovial fluid. Therefore, the results at an engineering standpoint could confirm that the artificial synovial fluid containing FN had a good performance to the vibration-proof effect.