Abstract
Photoacoustic spectroscopy is an alternative technique for noninvasive glucose monitoring of diabetic patients. The incident near-infrared light penetrates a few millimeters into human tissue and generates an acoustic wave that is derived from the optical absorption. The photoacoustic signal is detected by a piezoelectric transducer, and the glucose concentration in human tissue is estimated from the magnitude of the signal. Several studies have been carried out to eliminate the numerous optically interfering components in human blood and tissue. In this paper, in vivo and in vitro photoacoustic measurements of glucose are reviewed and a highly sensitive photoacoustic sensor that uses a Pb(Zn1/3Nb2/3)O3-PbTiO3 (PZNT91/9) single crystal with an extremely large piezoelectric constant g33 is described.
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