肺纤维化形成分子机制研究

Abstract

肺纤维化为慢性肺部疾病，特发性肺纤维化(IPF)为其主要类型，也是最严重的纤维化类型，其中位生存期仅为3年。目前肺纤维化发生机制尚不明确，主要研究炎症和免疫学机制、氧化应激和氧化信号通路、促凝机制等领域。本文就三项主要研究领域做一简要综述。 Pulmonary fibrosis is a chronic lung disease. Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of the disease, with a median survival of three years. Despite the fact that the precise mechanisms that drive fibrosis in patients remain incompletely understood. Three broad areas have been explored: inflammation and immune mechanisms, oxidative stress and procoagulant mechanisms. This paper gives a brief overview of three major research areas.