Abstract
The incidence of ischemic heart desease (IHD) in familial hypercholesterolemia (FH) was studied in 241 heterozygous and 12 homozygous patients.In a total of 241 heterozygous patients, 118 were males and 123 females. IHD was observed in 46 and 41% of the males and females. The mean age of 24 males and 38 females with coronary insufficiency, and 30 males and 13 females with myocardial infarction was 49±9, 56±12, 49±11 and 65±6 (Mean±S.D.) years, respectively. The mean age of 5 males and 3 females died from myocardial infarction and 4 males and 2 females died from sudden death was 51±16, 63±1, 47±9 and 75±3 years, respectively. These results suggested that IHD was not only more frequent and precorcious in males with heterozygous FH but also more severe than in females.There were 6 males and 6 females with homozygous FH. Four patients died from sudden death or heart failure. The mean age of death was 28 years (16-42 years). There was no cerebral or peripheral vascular insufficiency.
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