Abstract
For substitution of oxygen transporting ability in blood stream, artificial red cells have been widely developed for recent years. Since the role of the other blood components can be replaced by synthetic molecules (chemical regents), the realization of artificial O2-infusion leads to complement of the artificial blood based on the present transfusion techniques. This review describes the recent topics of the development of artificial red cells, especially on hemoglobin (Hb) based materials and totally synthetic lipidhemes. The Hb vesicles (HbV, cellular type) with appropriate O2-binding ability have several advantages in comparison to the acellular types such as crosslinked Hb. The results of animal tests clearly represented the in vivo oxygen delivery by HbV. On the other hand, molecular assemblies of synthetic lipidhemes act as O2-carrier under physiological conditions, More recently, albumin heme hybrid has also been developed as a new type of the O2-infusion series.
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