Abstract
Effects of chlorpromazine (CPZ) on serum GPT (SGPT) and hepatic microsomal drug-metabolizing enzyme activities in the rat with liver injured by CCl4 were studied.Rats were intraperitoneally injected with CCl4 at a dose of 0.2ml/kg every 3 days, and with CPZ at a dose of 5 mg/kg once a day for 48 days. SGPT activity was gradually elevated from the beginning of CCl4-administration and reached to the maximum after 30 days.The elevation of SGPT value induced by CCl4-administration was inhibited by the administration of CPZ.In addition, decreases of cytochrome P-450 and cytochrome b5 by CCl4-administration were observed.However, CPZ restored the decrease of cytochrome P-450.These results indicate that CPZ protects liver cell damage induced by CCl4, resulting in that the effect of CPZ on cytochrome P-450 may be important for protecting from drug-induced hepatic injury.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
