Abstract
Receptor-mediated endocytosis(RME) is now well recognized as a polypeptidc clearance system. In addition, a drug delivery system (DDS) via RME has been developed to deliver some drug specifically into the target cell expressing receplors on its plasma membrane. Therefore, kinetic analysis of RME process is important, both to clarify the pharinacokinetics of polypeptide itself and to estimate the efficiency of drug targeting. We have been studying kinetically both the hepatic and renal handling of epidermal growth factor (EGF) using in vivo, perfused organ, and isolated cell system. Such an analysis enables us to determine the kinetic parameters for the construction of a kinetic model for RME. Based on such a kinetic model, we can discuss the contribution of each process in RME on the efficiency of drug delivery into the cell.
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