白血球遊走試験による薬剤過敏性血液障害の検討

Abstract

The leukocyte migration test (LMT) was performed on 54 patients suspected to be suffering from drug-induced blood disorders in order to identify the allergenic drugs responsible. It was also performed on 42 patients who had been receiving the drugs but had not manifested any allergic symptoms (patients without hypersensitivity to drugs).Leukocytopenia was noted in 72.2% of the 54 patients suspected of suffering from drug-induced blood disorders, throm-bocytepenia in 42.6% and erythrocytepenia in 42.2%. The positive rates for the LMT were 66.7% in these 54 patients and 7.1% in the 42 patients without hypersensitivity showing that the positive rate was significantly higher in the patients suspected of suffering from drug-induced blood disorders than in the patients without hypersensitivity to the drugs (p<0.0001, X2-test). The positive LMT rate was 88.5% in a short latent period (<10 days) group and 46.4% in a long latent period (10 days) group. Thus, the LMT positive rate was significantly higher in the short latent period group than in the long latent period group (p<0.01, X2-test). In addition, the incidence of serious blood disorder cases was significantly higher in the short latent period group than in the long latent period group (p<0.01, X2-test).Our findings indicate that the LMT is a valuable method for identifying allergenic drugs in drug-induced blood disorders and that drug allergies are greatly involved in the pathogenesis of short latent period blood disorders.